Could your diabetes medicine be causing your
arthritis? Next DPP-4 Inhibitors for Diabetes Can Cause Severe
Joint Pain, FDA Says Robert Lowes writing for Medscape reported
dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes may cause joint pain so
intense it is disabling, the US Food and Drug Administration (FDA) warned today.
Fortunately, the pain goes away, usually in less than a month, once patients stop taking
the medicine. The agency said it identified 33 cases of
severe joint pains associated with DPP-4 inhibitors from October 16, 2006, through December 31,
2013, in its FDA Adverse Event Reporting System database. Twenty-eight of the cases involved
sitagliptin (Januvia, Merck & Co, Inc). Sitagliptin accounts for more than 80% of all DPP-4 prescriptions
in the country, according to a spokesperson for Merck.
Saxagliptin (Onglyza, AstraZeneca), linagliptin (Tradjenta, Boehringer Ingelheim Pharmaceuticals),
alogliptin (Nesina, Takeda Pharmaceutical Company), and vildagliptin, which is not marketed
in the United States, accounted for the rest of the 33 cases.
Comment: Wow… I didn’t know that.