How Do Pain Relievers Work? – George Zaidan

How Do Pain Relievers Work? – George Zaidan


Translator: Ido Dekkers
Reviewer: Ariana Bleau Lugo Say you’re at the beach,
and you get sand in your eyes. How do you know the sand is there? You obviously can’t see it,
but if you are a normal, healthy human, you can feel it, that sensation of extreme discomfort,
also known as pain. Now, pain makes you do something, in this case, rinse your eyes
until the sand is gone. And how do you know the sand is gone? Exactly. Because there’s no more pain. There are people who don’t feel pain. Now, that might sound cool, but it’s not. If you can’t feel pain, you could
get hurt, or even hurt yourself and never know it. Pain is your body’s early warning system. It protects you from the world
around you, and from yourself. As we grow, we install pain detectors
in most areas of our body. These detectors
are specialized nerve cells called nociceptors that stretch from your spinal cord
to your skin, your muscles, your joints, your teeth and some
of your internal organs. Just like all nerve cells,
they conduct electrical signals, sending information from wherever
they’re located back to your brain. But, unlike other nerve cells, nociceptors only fire if something
happens that could cause or is causing damage. So, gently touch the tip of a needle. You’ll feel the metal,
and those are your regular nerve cells. But you won’t feel any pain. Now, the harder you push
against the needle, the closer you get
to the nociceptor threshold. Push hard enough,
and you’ll cross that threshold and the nociceptors fire, telling your body to stop doing
whatever you’re doing. But the pain threshold isn’t set in stone. Certain chemicals can tune nociceptors,
lowering their threshold for pain. When cells are damaged,
they and other nearby cells start producing these tuning
chemicals like crazy, lowering the nociceptors’
threshold to the point where just touch can cause pain. And this is where over-the-counter
painkillers come in. Aspirin and ibuprofen block production of one class
of these tuning chemicals, called prostaglandins. Let’s take a look at how they do that. When cells are damaged, they release
a chemical called arachidonic acid. And two enzymes called COX-1 and COX-2 convert this arachidonic acid
into prostaglandin H2, which is then converted
into a bunch of other chemicals that do a bunch of things, including raise your body temperature,
cause inflammation and lower the pain threshold. Now, all enzymes have an active site. That’s the place in the enzyme
where the reaction happens. The active sites of COX-1 and COX-2 fit arachidonic acid very cozily. As you can see, there is no room to spare. Now, it’s in this active site
that aspirin and ibuprofen do their work. So, they work differently. Aspirin acts like a spine
from a porcupine. It enters the active site
and then breaks off, leaving half of itself in there, totally blocking that channel
and making it impossible for the arachidonic acid to fit. This permanently deactivates
COX-1 and COX-2. Ibuprofen, on the other hand, enters the active site, but doesn’t break apart
or change the enzyme. COX-1 and COX-2 are free
to spit it out again, but for the time
that that ibuprofen is in there, the enzyme can’t bind arachidonic acid,
and can’t do its normal chemistry. But how do aspirin and ibuprofen
know where the pain is? Well, they don’t. Once the drugs are in your bloodstream, they are carried throughout your body, and they go to painful areas
just the same as normal ones. So that’s how aspirin and ibuprofen work. But there are other dimensions to pain. Neuropathic pain, for example, is pain caused by damage
to our nervous system itself; there doesn’t need to be
any sort of outside stimulus. And scientists are discovering
that the brain controls how we respond to pain signals. For example, how much pain
you feel can depend on whether you’re paying attention
to the pain, or even your mood. Pain is an area of active research. If we can understand it better, maybe
we can help people manage it better.

100 comments on “How Do Pain Relievers Work? – George Zaidan

  1. Mr. Trees Post author

    Fell on my shoulder and haven’t been able to lift it cause it hurts so much.
    Had some ibuprofen and it worked so much it interested me. Here I am.
    Now I know how pain works and how these magic science pills work.
    So cool man…

    Reply
  2. banana slam this dick Post author

    Thanks I currently how have strep throat so I’m trying to figure out of the pill works

    Reply
  3. Z- Type Post author

    You forgot to talk about the only type of pain that is not produced by tissue damage…

    The ischemic pain.

    Reply
  4. Jessica Abbot Post author

    This Video is Quite Interesting. If you guys ordering something online make sure this is from a Legit Person, i've known somebody for years, her name is Ana and she's from California. She's a very good person and helped me a lot with my Percocet and other Meds like for Anxiety. Go ahead and leave her a message [email protected] she might be able to help you also

    Reply
  5. AduptUniform26 Post author

    Who else decided to poke and punch yourself just to see if your normal

    Just me ok

    Reply
  6. Milk Post author

    my right hip started to hurt for some reason and I just went on a downward spiral of how painkiller work then I just took paracetamol and hope it'll work.

    Reply
  7. Divine Dragoon Post author

    Wait one time a glass shard flew across my leg and cut it. I couldn’t feel any pain when that happened or after. The only pain I endured was when I touched it. Why did this happen?
    Also the cut was very deep

    Reply
  8. Mochi Mochi Post author

    Got a root canal 6 months ago and it was done by a pretty shatty dentist. So, my tooth cracked vertically and i’m literally dying of pain right now so i decided to educate myself a little while waiting for the painkiller to kick in

    Reply
  9. Laci Kaix Post author

    This helped me understand my condition of fibromyalgia a little better. Of how it works more or less.

    Reply
  10. Brandon Hoffman Post author

    Is there some advantage to ibuprofen’s approach of not permanently deactivating the enzyme as opposed to aspirin?

    Reply
  11. sach Ab Post author

    If you have pain, cure you sickness. Take pain meds for a short period of time, and try to cure! Don't let them make profits on your sickness, they will try to give you pills for ever… Money money money.

    Reply
  12. SHA APS LTD Post author

    Pain relievers are medicines that reduce or relieve headaches, sore muscles, arthritis, or other aches and pains. There are many different pain medicines, and each one has advantages and risks.

    Check Pain Relief Medications www.medicianonline.com

    Over-the-counter (OTC) medicines are good for many types of pain. There are two main types of OTC pain medicines: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs.

    If OTC medicines don't relieve your pain, your doctor may prescribe something stronger. Many NSAIDs are also available at higher prescription doses. You must use them only under a doctor's supervision.

    There are many things you can do to help ease pain. Pain relievers are just one part of a pain treatment plan.

    Where to get Pain Relief Medications www.medicianonline.com

    Reply
  13. PoSeiDoN NaGa Post author

    I fractured my spine L4 in a car accident 7years ago and it's a nightmare living in pain each day. My tolerance to Painkillers increased and my dose became addictive. I'm now living on OST but ibuprofen isn't doing much. Can I get something else?

    Reply
  14. Alan Doherty Post author

    What bout people like me who may use medicines and still have no feelings of relieving pain.
    (immune to the pain medicine)

    Reply
  15. Lawrence Jin Post author

    Can't take aspirin yet (cause I'm still a kid), ibuprofen destroys my stomach, so what do I turn to for headach relief????? Talynol!!!

    Reply
  16. Diego Belaunde Post author

    Here because I went to a metal concert last night and I head banged my heart out, so now my neck is sore lol

    No regrets tho🤘🏽🤘🏽

    Reply
  17. Lauren T Post author

    I find if I go into a form of meditation and concentrate on the pain and the area it is in, I can reduce the pain. It's hard to explain but I try to imagine the pain, like the images in this video, and imagine calming them down and letting them float away, and it does seem to ease the pain yo some degree! Also I am often in pain as I have Fibromyalgia!

    Reply
  18. Pip Ans Post author

    This acid reflux disease treatment “Dοcuzu Rαkα” (Gοοgle it) has brought me extraordinary results immediately after just 10 days of continuously adhering to the treatment plan. Gastric acid and also acid reflux signs and symptoms that have driven me in pain for a long time are right now gradually leaving me permanently. .

    Reply
  19. Epickittycat Hitt Post author

    For this reason acid reflux disease treatment solution “Dοcuzu Rαkα” (Gοοgle it), I was able to treat my digestive problems. There`s no problem in testing this medication. You will never know this might handle your digestion issues as well as chronic acid reflux.. .

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  20. Oswell Subscriptions Post author

    Why would we create pain to help us know we're in danger but then make it such a terrible experience to go through? I don't think that is the main use of pain

    Reply
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